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DaTQUANT™

A quantitative analysis of dopamine transporter (DaT) SPECT images now at your fingertips.

An aid in the assessment of the degree of in vivo expression of the dopamine transporter (DaT)

• DaTQUANT assists in the detection and quantification of the loss of functional striatal dopaminergic neuron terminals, a loss correlated with Parkinson's disease
• Quantitative analysis may help assess the extent and intensity of the striatal 123I-ioflupane signal


Quantification results are indicated for left and right striatal binding ratios, putamen/caudate ratios, and left/right asymmetry. Values are for illustrative purposes only.

Automated processing ensures objective, accurate, and reproducible results

• Uses a predefined 123I-ioflupane VOI template for automatic asymmetry measurements and putamen/caudate update ratios
-Offers the option for manual adjustment of VOI placement
-95% of more than 200 images tested required no user intervention for VOI placement adjustment1
• Reduces variation in comparison to normal database by reconstructing SPECT data with same parameters applied to normal database
• Orients the image automatically for optimal visual assessment and removal of head-tilt artifacts

A normal database developed from healthy volunteers who contributed to the Parkinson's Progression Markers Initiative, a comprehensive study of patients with Parkinson's disease2

• In less than one minute, generates quantification results including comparison to age-matched normal volunteers.
• Normal database has been validated for use with images acquired on a variety of multiheaded SPECT cameras
• Users have the ability to create a customized normal database that enables comparison to a site-specific normal population of images

DaT, dopamine transporter; SBR, striatal binding ratio; VOI, volume of interest; SPECT, single-photon emission computed tomography; PDF, portable document format; DICOM, Digital Imaging and Communications in Medicine; PACS, picture archiving and communication system

References:
1. Internal verification testing data on file. GE Healthcare; 2015.
2. Parkinson's Progression Markers Initiative. PPMI-info.org. Accessed 2018.

Indication

Medical Device Indication

The DaTQUANT Software application enables visual evaluation and quantification of 123I-ioflupane (DaTscan) images. DaTQUANT normal database enables quantification relative to normal population databases of 123I-ioflupane (DaTscan) images.

This application may assist in detection of loss of functional dopaminergic neuron terminals in the striatum, which is correlated with Parkinson’s disease.

Additional Features

Addition to the DaTQUANT platform

Longitudinal image analysis to aid in the assessment of disease progression

  • Enables access to both a visual and a quantitative comparison of one patient’s images at two separate time points

A comprehensive report of dopaminergic transporter density for your referring physicians

  • Automatically generates a comprehensive PDF report that combines both visualization and quantification reports 
       - Application screens can be saved as DICOM® screen captures and uploaded to a PACS
  • Customizable reports and statistical analyses (options of images, ratios, and/or visually plotted comparison to normal database)

DaTQUANT Software for your PC offers expanded accessibility and reading flexibility

  • Now available in a stand-alone, PC-based version
  • Expanded normal database derived from the comprehensive Parkinson’s Progression Markers Initiative
  • Automatic processing to enable object, accurate, and repeatable results
  • Longitudinal analysis to enable comparison of one patient’s images over time

PDF, portable document format; DICOM, Digital Imaging and Communications in Medicine; PACS, picture archiving and communication system; PC, personal computer.

System Requirements

  • Minimum 4GB RAM
  • 60GB hard drive (only 250 MB free space is needed)
  • Windows 7,8, or 10 (32 or 64-bit versions supported)
  • Minimum monitor resolution of 1024x768 true color (24-bit depth)
  • Easy self-installation (high-speed Internet connection required to download software)

Contact and Help

For ordering and billing questions, please call Customer Service at 800 292 8514

For clinical questions and applications support related to DaTQUANT, you can reach Medical Affairs at 800 654 0118 (option 2, then option 3) or professional.services.medical@ge.com

For technical support installing or running the DaTQUANT Software, please call Technical Support at 800 437 1171

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