A new era in personalized imaging with quantitative PET/MR

When we first introduced Time-of-Flight (TOF) technology on a fully integrated PET/MR system, we said it would be revolutionary. We delivered on that promise and now we are taking it even further.

Introducing SIGNA™ PET/MR with QuantWorks. Built with pioneering TOF and integrated with a 3.0T MR, its impressive quantitative accuracy and high count rate combined with innovative Q.Clear reconstruction delivers 2x improvement in image quality. In addition, SIGNA PET/MR with QuantWorks includes a comprehensive suite of applications and flexible research tools to pursue ideas that could influence the future of medicine.

SIGNA PET/MR with QuantWorks is not available for sale in all regions.

  • Fueling the Future of MR

    Our SIGNA™Works productivity platform redefines what’s possible. Acquire calculated, quantitative ADC maps with MAGiC DWI. Streamline post-processing for higher efficiency and enhanced workflow with the amazing capabilities of ImageWorks and improve image quality up to eight times faster with our HyperWorks applications.

    Learn more about SIGNA™ Works and its innovative applications

Light Tight RF Shield with copper coating



Lutetium Based Scintillator (LBS) crystal array with light and Enhanced Spectral Reflectors (ESR)



SiPM - Silicon PhotoMultiplier with circuit boards/ASICS

Thermal coupling gasket


Aluminum mounting plate

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The full diagnostic potential of high sensitivity and TOF

SIGNA PET/MR with QuantWorks is built with proprietary Silicon PhotoMultiplier (SiPM) detectors and the exceptional sensitivity of 25 mm deep Lutetium-based crystals. The result is a fully integrated PET/MR with high sensitivity and TOF capability.

In addition, our innovative Q.Clear reconstruction leverages the excellent signal-to-noise ratio (SNR) enabled by TOF. And our Zero Echo Time (ZTE) MR substitutes X-ray based attenuation correction with ionizing-radiation-free MR in the head. This combination of improvements to image quality and quantitation accuracy enables you to embrace the full potential of PET/MR.

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Trust with consistently accurate results.

When you can trust the accuracy of each result, quantitation takes on a whole new meaning.

SIGNA PET/MR with QuantWorks combines the clarity of our TOF technology with the consistency of Q.Clear. Using innovative reconstruction, Q.Clear incorporates prior knowledge about image quality into reconstructed images to decrease noise while providing quantitation accuracy and significantly improving image quality. In addition, SIGNA PET/MR with QuantWorks includes the most comprehensive motion correction package in the industry to reduce the effects of involuntary and physiological motion. And our ZTE MR, a true ZTE imaging technique, can ‘see’ bone for an ionizing-radiation-free attenuation correction method with MR.

This exclusive combination of TOF technology and Q.Clear provides you with another tool you can rely on to confidently guide the decisions that impact patient care.

Reduced noise


Q.Clear incorporates prior knowledge about image quality into the reconstructed image to decrease noise while providing quantitation accuracy and significantly improved image quality.

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ZTE MR replaces the X-ray based gold standard for attenuation correction with this accurate, personalized ionizing-radiation-free MR technique. Based on the high stability of SIGNA PET/MR with QuantWorks’ hardware, our ZTE MR is more reliable and faster than Ultra Short Echo (UTE) and improves image quality.

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Comprehensive Motion Correction Solutions

Solutions to reduce involuntary and physiological movement with an extensive selection of motion correction applications for PET and MR, including PROPELLER, PROMO and Pencil Beam Navigator.


The new standard is extraordinary

Our new SIGNA™Works applications portfolio redefines productivity and improves security across the breadth of our core imaging techniques. SIGNA PET/MR with QuantWorks comes preloaded with the standard applications portfolio of SIGNA™Works as a fully integrated package. This extensive library of high quality and efficient imaging techniques enables you to achieve the outcomes you desire across your entire practice.

SIGNA™Works’ advanced applications include HyperWorks, ViosWorks, ImageWorks and SilentWorks, which further advance diagnostics and accelerate throughput while simultaneously improving patient outcomes and your ROI.

Not only is SIGNA™Works upgradeable, it can be further customized, so you have the flexibility to add applications to suit the needs of your practice.


Phenomenal exams to meet your clinical needs
  • BodyWorks

    With BodyWorks, we address one of the fastest growing areas in MR. This all-inclusive library allows you to image abdominal and pelvic anatomy with user flexibility to adapt to different patient types.

    Auto Navigator is GE's solution to combat respiratory motion in abdominal imaging. This free-breathing approach is compatible with multiple pulse sequences including diffusion, PROPELLER MB, MRCP and dynamic T1 imaging.
  • CVWorks

    With our intuitive cardiac techniques, you can assess morphology, flow, function and tissue viability plus gain crucial insights into vascular structure and flow dynamics. CVWorks provides the flexibility to adapt to different patient types with exams that vastly simplify workflow.

    With CVWorks, multi breath-hold imaging can be a thing of the past. Our latest Single shot MDE and Black Blood techniques provide patient-friendly alternatives to uncomfortable breath-holds.

    With our workflow-simplified QuickStep protocols, scanning whole body vasculature can be done in less than 6 minutes. High performance gradients allow bright blood pool and myocardial tissue contrast on Cine FIESTA while preserving spatial resolution.
  • NeuroWorks

    This one-stop solution enables you to imagine brain, spine, vascular and peripheral nerve anatomy with exceptional tissue contrast. These motion-insensitive techniques feature single-click auto alignment, providing the complete neuro solution from scanning to post processing.

    NeuroWorks also includes Cube, our 3D volumetric imaging suite, standard with every system. This application allows you to suppress CSF and either white or gray matter to increase lesion conspicuity.

    PROPELLER MB, our latest PROPELLER enhancement, is a multi-shot approach that preserves tissue contrast regardless of weighting while also reducing motion artifacts. Additionally, this new technique introduces new contrasts such as T1 FSE.
  • OncoWorks

    This extensive library of techniques captures anatomic and morphologic data to uniquely enable oncological assessment of anatomy. OncoWorks includes robust tissue contrast, motion-insensitive, high temporal and spatial resolution imaging.

    3D volumetric imaging with an optimized adiabatic fat suppression, combined with ARC or ASSET, provides high spatial and temporal resolution to capture contrast uptake patterns. The FSPGR Ax Dynamic image shows lesion characteristics generated using AW VS7's positive enhancement map. The T2 PROPELLER image demonstrates small FOV and motion-correction through the prostate.
  • OrthoWorks

    This one-stop solution enables you to image brain, spine, vascular and peripheral nerve anatomy with exceptional tissue contrast. Includes ReadyBrain for single-click auto alignment, enabling patient planning through post processing.

    This extensive library of musculoskeletal imaging techniques enables you to image bone, joint and soft tissue with remarkable tissue contrast.

    OrthoWorks also includes 3D volumetric Cube with proton-density, combined with ASPIR, which enables improved fat suppression uniformity, which is routinely done as three separate 2D scans. With one 3D acquistion and multi planar reformats, Cubes may replace individual 2D scans.
  • PaedWorks

    Pediatric imaging requires exclusive and distinctive imaging techniques that provide ease of use for the user and clinical excellence for your smallest, most fragile patients.

    PaedWorks provides specialized protocols to simply address the needs of your smallest, most fragile patients. Techniques such as PB Navigators combined with PROPELLER MB are used with advanced techniques like diffusing imaging, allowing for patient-friendly, entirely free-breathing exams. Additionally, cardiac exams using single shot MDE provide faster, more reliable results.

    The four images demonstrate dynamic T1 imaging with PB Navigator, which enables the patient to breathe freely while capturing contrast in fast temporal phases. Whole spine evaluation can be obtained simply with routine T2 frFSE imaging.


Broaden your areas of expertise

New avenues of discovery

Explore all that PET/MR is capable of by using SIGNA PET/MR with QuantWorks’ extensive offering of research tools.

SIGNA PET/MR with QuantWorks has the tools you need to discover disease-specific tracers and develop new protocols. You can use PET/MR simultaneously with MR multinuclear spectroscopy as an in-vivo laboratory to study fast biochemical processes. In addition, PET ToolBox and Orchestra Software Development Kit give you offline access to our image reconstruction environments for PET and MR making it faster and easier to work on your own reconstruction ideas.

SIGNA PET/MR with QuantWorks provides the tools you need to push the boundaries of its innovative technology.

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Orchestra Software Development Kit

Directly access SIGNA PET/MR with QuantWorks’ image reconstruction environment offline and work with raw image data without having to be at the scanner.

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PET ToolBox

Develop novel PET imaging techniques using our software tools to access the PET image reconstruction environment.

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Organ-Specific Applications

Segment, measure and compare volumetric brain images to normal brain images with NeuroQuant MR for objective support when identifying neurodegenerative diseases.

Analyze brain studies with beta amyloid and FDG tracers and compare them to FDG normals with CortexID multimodality package.

Get a comprehensive cardiovascular assessment with ViosWorks in one free-breathing, eight-minute scan that provides quantitative 3D information for cardiac anatomy, function and flow.

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In-vivo Laboratory

Images acquired separately courtesy of UCSF and University Hospital Zurich

Simultaneously use PET/MR with MR multinuclear spectroscopy as an in-vivo laboratory to study fast biochemical processes.

Supporting Materials