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TRACERlab FX C Pro Chemistry Synthesizer

rmacy-tracer-center-equipment-tracerlab-fx-c-pro-chemisty-synthesizers-tracerlab fx2 c.jpg

The TRACERlab FX2 C Synthesizer is an automated, integrated system for easy and efficient 11C-based tracer production.

The TRACERlab FX2 C, evolution of the TRACERlab FX C Pro, is an automated system for easy and efficient production of 11C based tracers.
TRACERlab FX2 C combines flexibility and productivity. It provides [11C]methyl iodide or [11C]methyl triflate production and methylation of PET tracers in one module. For labeling processes starting directly with [11C]CO2 the methylation step can be bypassed.
More than 50 tracers have been produced and published using TRACERlab FX C Pro, the predecessor product of TRACERlab FX2 C and TRACERlab FX2 C can run all these synthesis methods too

Benefits

Easy-to-Use 11C Tracer Production

The TRACERlab 11C tracer platforms are designed to formulate final tracers with minimal operator intervention. The system allows you to:

  • Save time through automation
  • Achieve high yield
  • Deliver high specific activity
  • Control incoming gases

Technology

The TRACERlab FX2 C integrates all necessary components for the production of 11C-based tracers in one module:

  • Trapping of [ 11 C]carbon dioxide or [ 11 C]methane
  • Patented gas-phase synthesis of [ 11 C]methyl iodide and [ 11 C]methyl triflate with high specific activity
  • Labeling reactor with heating, cooling, stirring features
  • Built-in semi-preparative HPLC purification
  • Built-in formulation of the final tracer
  • Gas and liquid system sealed against room air

Specifications

TRACERlab FX2 C specifications include:

System Characteristics

Size (W x H x D) of main module

50 cm x 48 cm x 45 cm

Weight of main module

40 kg

Control electronics

29 cm x 21 cm x 8.5 cm

6 Radiation detectors

[ 11C]CO 2, [ 11C]CH 4, [ 11C]MeI, labelling reactor, HPLC,
product vial

Labelling reactor

Borosilicate glass, 9 mm ID, v-shape, magnetic stirrer,
heating up to 200°C, cooling down to -100°C.
Retractable reactor needle.

Reagent vials

3 for the labelling reactor
3 for the formulation subsystem

Purification subsystem

Isocratic HPLC controlled by the synthesis software
Gamma radiation and UV (190-500 nm D 2) detectors

Formulation subsystem

Solid phase extraction with stirred dilution flask

Configuration

Performance

Cyclotron

Target

[ 11C]MeI Yield

[ 11C]MeI specific activity A [GBq/µmol]

Intrinsic formation of cold MeI [nmol/run]

PETtrace

CH 4

37% ± 7%

1000 B

< 20

PETtrace

CO 2

37% ± 7% A

400 B C

< 25

A Using purifiers for target gases input
B Indicative values only, valid in combination with GE PETtrace cyclotron, not suitable for acceptance
C At 75 GBq (2 Ci) [ 11C]CO 2.

Have a question? We would love to hear from you.

JB04708XX