Heart Care

• 50% of untreated patients with onset symptoms of Aortic Stenosis die within 2 years2
• 5 Million Americans are diagnosed with aortic valve stenosis each year 2

Minimally invasive therapies for CVD are increasing

1. Most common cause of death worldwide. http://www.who.int/cardiovascular_diseases/en/
2. According to the American Heart Association (AHA), more than 5 million Americans are diagnosed with aortic valve stenosis each year. An estimated 1.5 million people suffer from aortic stenosis in the United States with prevalence of 5% over 75 years of age. Patients with aortic stenosis have congested blood flow across the aortic
   valve in the heart and are at high surgical risk. Over 10 to 20 years, these patients experience noticeable symptoms, such as chest pain and heart failure, with mortality
   rates at 1 year and 2 years at approximately 25% and 50%, respectively. The Global Emerging Interventional Cardiac Devices Market Increasing Adoption of New
   Technologies in Emerging Markets Provides Impetus to Growth - Frost & Sullivan - ND01-54 - February 2014

* IGS 3 series refer to Optima IGS 320 or Optima IGS 330