Tauroselcholic [⁷⁵Se] Acid
Chronic diarrhoea presents a difficulty in diagnosis
Persistent chronic diarrhoea is a problem in clinical practice that is often difficult to diagnose and treat.1
1 in 20 people may suffer from chronic diarrhoea, making it one of the commonest referrals to a GI clinic.2
More specifically it affects 3 million people in the UK and the total prevalence of chronic diarrhoea in a Western population is estimated in 4-5%.3
Diagnostic difficulty often leads to numerous visits to doctors and clinics, with investigations which may not lead to a definitive diagnosis .3
There can be multiple causes for chronic diarrhoea including Irritable bowel syndrome (IBS), Inflammatory bowel disease (IBD), Bile Acid Diarrhoea (BAD).1
BAD is a common cause of chronic diarrhoea affecting a large population
BAD is the diarrhoea caused by bile acids and has historically been referred to as bile acid malabsorption.4
The data below show the number of patients presenting with chronic diarrhoea who were shown to have underlying BAM5
The prevalence in chronic diarrhoea is high, as a recent study indicated that the main cause of this diarrhoea was IBS, while diarrhoea caused by Bile Acid (SeHCAT retention <15% at 7 days) was the fourth leading cause6.
Thus, BAD can be very common, affecting 1 % of the general population, which equates to approximately 10 million people in North America and Europe alone. 7
1. Smith MJ et al. J R Coll Physicians Lond 2000; 34 (5): 448-51.
2. Thomas PD et al. Gut 2003; 52: 1-15.
3. NICE diagnostics guidance [DG7] 2012.
4. Mottacki N et al. Alliment Pharmacol Ther 2016; 43 (8): 884-98.
5. Basumani et al. Bile Acid Malabsorption: Two Decades On. Gut 2008; 57 (Suppl I): A1-A172.
6. Kurien M, Chaudhary S, McConnell JR, Leeds JS, Sanders DS. Pharmacol Ther. 2014 Jul;40(2):215.
7. Gupta A et al. Support Care Cancer 2015 1-10