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Tauroselcholic [⁷⁵Se] Acid

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Tauroselcholic [⁷⁵Se] Acid

Gold standard diagnosis of BAD, an underlying cause of chronic diarrhoea.

Open the door to freedom from chronic diarrhoea with SeHCAT

Chronic diarrhoea is one of the top reasons for referral to a gastrointestinal clinic. It is estimated that chronic diarrhoea affects the 4-5% of the western population1

The causes are multiple in adults and the underlying cause is often difficult to ascertain. As a result, the patients may undergo several investigations without a definitive cause being identified.2

Bile Acid Diarrhoea is common and is often diagnosed as IBS-D

  • Bile Acid Diarrhoea (BAD), is common and likely under-diagnosed. It is the diarrhoea caused by excess bile acids reaching the colon and historically had been referred to as bile acid malabsorption.4
  • For many patients the diagnosis can take more than 5 years with significant impact not only on their physical and mental health but also on well-being.3
  • It is estimated that 1/3 of patients with a diagnosis of functional diarrhoea or IBS-D may have a component of bile acid diarrhoea.4,8 On this basis, half a million patients in the NHS treated for IBS-D, could have BAD, for which potential diagnosis and effective treatment is available.1

Diagnosing BAM diarrhea

SeHCAT is an accurate method for diagnosing BAD

  • SeHCAT is a simple, accurate and non-invasive diagnostic tool for BAD that can support clinicians' decision.5
  • It is absorbed and excreted at the same rate as cholic acid but is resistant to metabolism.6
  • SeHCAT is a diagnostic gold standard for BAD because of its sensitivity, specificity, safety profile and low cost.7
  • Early diagnosis with SeHCAT can also prevent other investigations with a lower likelihood of diagnosis and greater associated costs and complications.4

Early diagnosis of BAD is predicted to increase quality of life for patients

  • Early diagnosis of BAD is predicted to lead to decreased morbidity, increased quality of life and fewer referrals to gastroenterologists.3
  • Accurate diagnosis of BAD with SeHCAT, strengthens the case for continuing with Bile Acid Sequestrants therapy which, could lead to improvements in symptoms and quality of life.5


  1. NICE diagnostics guidance [DG7] 2012.
  2. Riemsma R., et al. 61, 2013, Health Technology Assessment, Vol. 17
  3. Bannaga A, et al. BMJ Open Gastroenterol 2016;3:e000116
  4. Mottacki N et al. Alliment Pharmacol Ther 2016; 43 (8): 884-98.
  5. Smith MJ et al. J R Coll Physicians Lond 2000; 34 (5): 448-51
  6. SeHCAT SmPC 2016; GE Healthcare
  7. Mena Bares LM et al. Rev Esp Med Nucl Imagen Mol 2016.
  8. Fernández-Bañares F et al. Am J Gastroenterol 2007; 102: 2520-8
  9. JB7345A 10-2017
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The SeHCAT Test

What is SeHCAT?

SeHCAT is a synthetic bile acid, which is not metabolized by bacteria. After administration, it passes through the enterohepatic circulation as endogenous bile acids.1

SeHCAT is indicated for the investigation of bile acid malabsorption and measurement of bile acid pool loss. It may be used in the assessment of ileal function, in the investigation of inflammatory bowel disease and chronic diarrhoea and in the study of enterohepatic circulation.1

SeHCAT is a widely available test which is simple to perform

  • It is a widely available test which is simple to perform. SeHCAT offers a relatively low radiation dose to the patient (0.26mSv), compared to a typical upper gastro intestinal CT exam(6.0mSv).1,2
  • It is supplied as capsules of 370kBq at the activity reference date. Each capsule is one patient dose and contains less than 0.1mg of tauroselcholic acid.1
  • Selenium-75 has a physical half-life of approximately 118 days and decays by gamma emission with principal energies at 0.136 MeV and 0.265MeV.1
SeHCAT diagnostic capsule for bile acid diarrhea

Simple and accurate diagnostic capsule

SeHCAT is a simple, accurate and definitive test that can support clinicians' decision.3

The patient is given one capsule containing 370KBq SeHCAT, after oral administration in capsule form, it is secreted into the bile, reabsorbed from the small intestine and re-secreted.4

The percentage retention is measured on a gamma camera and a retention below 15% at seven days is considered to be abnormal, suggesting Bile Acid Diarrhoea.4

  1. SeHCAT SmPC 2016; GE Healthcare.
  2. US FDA What are the Radiation Risks from CT 2013.
  3. Smith MJ et al. J R Coll Physicians Lond 2000; 34 (5): 448-51
  4. Sinha et al. Aliment Pharmacol Ther 1998; 12:839-44.
  5. JB7345A 10-2017

Prescribing Information