TRACERlab FX F-E

TRACERlab™ FX F-E is an automated, versatile synthesizer for easy and efficient production of general [18F] tracers via electrophilic substitution with [18F] Fluorine in the form of F2.

Purification is achieved by an integrated, preparative HPLC system. Through application software, all process steps are easily programmed to efficiently produce the required tracers.


Features

 

  • 4 reagent vials
  • 3 formulation vials
  • 1 glass reactor (small) with magnetic stirrer and retractable needle
  • Sub-zero cooling of reactor (liquid nitrogen)
  • 3 Geiger-Müller counters
  • Vacuum system with cryogenic trap
  • Purification with preparative HPLC
    • 2 HPLC eluents
    • HPLC flow control
    • Automatic loop filling with fluid detector
    • UV and radioactivity HPLC detector
  • Fraction collection and dilution vessel
  • Solid phase extraction (SPE) HPLC solvent removal
  • Formulation of final tracer


Examples of [18F] Tracers
Tracer Molecular Level Disease Level
18F F-DOPA Dopamine synthesis Neurology
18F Fluoro-L-m-tyrosine Dopamine synthesis Neurology
18F Fluoro-L-tyrosine Protein synthesis, amino acid transport Oncology
18F Fluorouracil RNA component Oncology