Impact of Single-Voxel Spectroscopy (Probe SV) in routine clinical practice

The Probe2000 Option offers Single and Multiple Voxel Hydrogen Spectroscopy with Automated Water Suppression and Gradient Shimming. Spectroscopy results can be displayed as Individual Voxel Spectra or as Color Metabolite Maps.

	Figure A
A 57 year old male presents with left hemisensory deficit and increasing somnolence. MRI demonstrates an enhancing right ganglionic mass (Figure A) with central hyperintensity and surrounding edema on the T2-weighted and FLAIR images (Figures B & C).
Figure B		Figure C
Differential diagnosis favored a tumor, however, an abscess could not be excluded. Proton spectroscopy (PROBE-SV) (Figure D) demonstrated a surprising lack of choline (which would have indicated a tumor) with high lipid and lactate indicating membrane breakdown, necrosis, and anaerobic metabolism more suggestive of an abscess.
Figure D		Figure E
As this was early in our experience, the neurosurgeon insisted on an MR-guided brain biopsy which yielded toxoplasmosis (Figure E).
In AIDS patients, proton spectroscopy can often make the difference between biopsy and no biopsy for necrotic lymphoma vs. toxoplasmosis.
"In addition to Probe SV, GE's multi-voxel spectroscopy is easy-to-use and technologist-friendly and provides higher resolution spectra within 10 minutes" - - William G. Bradley, M.D.

Required Equipment for Clinical Case
Magnet: 1.5T
Gradients: Base, HiSpeed or EchoSpeed
Computer: LX 8.3 software

Software: Probe2000 Upgrade
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Software: Probe2000
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