PET/CT imaging

Clinical case - Sharpening in lesion delineation

   
 
     
  Who we are  
 
 
  Professor Juhani Knuuti
Director


Adj. Prof. Marko Seppänen
Diagnostic Service Manager


Turku PET Centre
Turku, Finland


As a Finnish National Research Institute, Turku PET Centre led by Professor J. Knuuti, promotes the use of PET in the medical research field. The Centre was founded in 1974 by the University of Turku, Åbo Akademi University and the Turku University Hospital. The Centre integrates top scientific expertise with excellent facilities and equipments. Fruitful interaction and collaboration between basic scientists and clinical investigators is a long-standing tradition.

 
 

The latest imaging technology is available, some unique in Europe. The Centre provides several tracers for routine and research clinical imaging in Oncology, Neurology and Cardiology, using the Europe's first 64 slices PET/CT system. With its excellent cyclotron and radiochemistry laboratories, Turku PET Centre develops and produces the latest PET tracers for clinical imaging.

 
 

Turku

 
     
  Patient History  
 
 
 

Female - 45 years old - 168 cm - 55 kg

This patient has been treated for a poorly differentiated breast cancer in 1998. Received post-operative radiotherapy. Suffered chest pain since 2006 and, thereafter, diagnosed lytic destruction in sternum for which she received palliative chemo-radiotherapy in fall 2007.

Referred to 18F-FDG PET/CT for re-staging purposes.

 
 

 

 
     
  Acquisition  
 
 
  Scanner: GE Discovery VCT  
     
  PET acquisition: Whole-body acquisition  
  3D acquisition using both VUE Point & VUE Point HD reconstructions  
  Acquisition time: 12 min  
  Post-injection time: 62 min  
  Dose: 370 MBq of 18F-FDG  
     
  CT acquisition: Low dose with shallow breathing without contrast media  
  Rotation speed: 0.8 second  
  FOV: 70 cm  
  Pitch: 1.375 mm/rot  
  Slice thickness: 3.75 mm  
  Smart mA, NI: 25, kVp: 140, mA: 80  
  Dose: 4 mSv  
       
     
  Findings  
 
 
 
Matrix of 256 x 256 pixels  

Whole-body static image – VUE Point HD

 
Matrix of 128 x 128 pixels   Matrix of 128 x 128 pixels  

VUE Point : Matrix of 128 x 128 pixels

 
Matrix of 256 x 256 pixels   Matrix of 256 x 256 pixels  

VUE Point HD : Matrix of 256 x 256 pixels

 
 
 

There are metabolically active lymph nodes in both sides of the supra clavicular region. In addition, a metabolically active lesion was found in the sternum representing bone metastasis. A suspicion of left adrenal gland metastasis was discovered.

 
     
     
  Conclusion  
 
 
 

Using a matrix of 256x256 pixels improved the diagnostic confidence since it is possible to better delineate all metastases. This is particularly evident in the left supra clavicular region where two different lesions are visible using 256x256 matrix compared to only one single lesion with 128x128 matrix (on the top). Using a matrix 256x256 pixels improves the staging confidence and may be beneficial for the radiotherapy planning.

 
 

 

 
 
Matrix of 256 x 256 pixels
 
   
   
   
   
   
   
     
Who we are  
Patient History  
Acquisition  
Findings  
Conclusion  
     
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