PET Radiopharmacy

TRACERlab FX F-N

TRACERlab FX F-N

TRACERlab™ FX F-N is an automated versatile synthesizer for easy and efficient production of [18F] tracers via nucleophilic substitution with [18F] F- Fluoride trapped from [18O] water.

Purification is achieved by an integrated, preparative HPLC system. Through application software, all process steps are easily programmed to produce the required tracers.

Features

Features

  • 6 reagent vials
  • 3 formulation vials
  • 1 glassy carbon reactor with magnetic stirrer and retractable needle
  • 4 Geiger-Müller counters
  • Vacuum system with cryogenic trap
  • 18O-water recovery
  • Intermediate solid phase extraction (SPE) Purification with preparative HPLC
    • 2 HPLC eluents
    • HPLC flow control
    • Automatic loop filling with fluid detector
    • UV and radioactivity HPLC detector
  • Fraction collection and dilution vessel
  • Solid phase extraction (SPE) HPLC solvent removal
  • Formulation of final tracer


Examples of [18F] Tracers
Tracer Molecular Level Clinical care area
18F labeled long chain fatty acids - 18F FTHA Anaerobic metabolism Cardiology
18F Fluoromisonidazole Hypoxia Oncology,
Cardiology
18F Methylbenperidol Dopaminergic D2 receptor Psychiatry
18F Methylspiperone Dopaminergic D2 receptor Psychiatry
18F Fluorostradiol Steriod metabolism Oncology
18F Altanserine Serotoninergic S2 receptor Psychiatry
18F FLT Fluoro-L-Thymidine DNA synthesis Oncology
18F FDG Glucose metabolism Oncology
Cardiology
Neurology